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Phencyclidine (PCP) overdose is primarily associated with various central nervous system effects, and seizures can indeed be a serious complication. PCP is known to exert its effects as a dissociative anesthetic, leading to symptoms such as agitation, hallucinations, and altered consciousness. In certain cases, excessive use or overdose can lead to seizure activity due to the drug's impact on neuronal excitability and possible alterations in neurotransmitter systems.

The development of seizures following PCP overdose reflects the direct excitatory effects of the substance on the brain. While PCP can cause symptoms of hyperactivity, cardiac issues, and even coma in some scenarios, seizures remain a particularly relevant and acute complication that can arise from its use, marking a critical area of concern in overdose situations.

Understanding these manifestations aids in the management and treatment of individuals experiencing PCP overdose, highlighting the importance of recognizing seizures as a significant potential consequence.